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KMID : 0043320110340122037
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Archives of Pharmacal Research
2011 Volume.34 No. 12 p.2037 ~ p.2041
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Cytotoxic lasiodiplodin derivatives from the fungus Syncephalastrum racemosum
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Buayairaksa Mongkol
Kanokmedhakul Somdej
Kanokmedhakul Kwanjai
Moosophon Panawan
Hahnvajanawong Chariya
Soytong Kasem
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Abstract
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Chemical investigation of fungal biomass of the fungus Syncephalastrum racemosum led to the isolation of new natural products (3R),(5S)-5-hydroxy-de-O-methyllasiodiplodin (1), 6-oxode-O-methyllasiodiplodin (2), in addition to five known compounds, de-O-methyllasiodiplodin (3), lasiodiplodin (4), (3R),(5R)-5-hydroxy-de-O-methyllasiodiplodin (5), ergosterol (6), and ergosterol peroxide (7). Their structures were elucidated by spectroscopic techniques. The absolute configuration of 1 was determined by a modified Mosher’s method. Compound 1 showed cytotoxicity against cholangiocarcinoma, KKU-M139, KKU-M156, and KKU-M213 cell lines with IC50 values in the range of 14?19 μg/mL, while 3 showed cytotoxicity against KB, BC1, and NCI-H187 cell lines with IC50 values of 12.67, 9.65, and 11.07 μg/mL, respectively.
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KEYWORD
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Syncephalastrum racemosum, Lasiodiplodin, Cytotoxicity, Cholangiocarcinoma
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